To compensate for this lack of data, information resulting from n-butyl acetate as supporting substance are used as substitute (read-across from supporting substance (structural analogue or surrogate). ** Thank you for your patience. tert-Butyl acetate, or t-butyl acetate is a colourless flammable liquid with a camphor- or blueberry-like smell. Start typing to see products you are looking for. The irritative effects were evaluated on the basis of the subjective feeling of irritation, clinical examination of eye irritation and the lung function. [7], Isoamyl acetate is released by a honey bee's sting apparatus where it serves as a pheromone beacon to attract other bees and provoke them to sting. Coronavirus: China shares in biggest fall in four years, Oil and gas industry outlines its plans to reach net zero emissions, Coronavirus and oil: Why crude has been hit hard, UK inflation in January rose to a six-month high. Slightly waxy notes (fresh, Narcisse-like ) are typical of the pure product, while unpleasant or pronounced animal-honeylike notes dominate the poorer grades.”, He goes on to tell use that it “Finds extensive use in perfumery for fresh ‘petal’ notes in Rose, Peony, Narcisse, Carnation, Sweet Pea, Freesia, Hyacinth, etc.”. In the third part of the study, subjects were exposed to 70 and 700 mg/m³ n-butyl acetate (14.5 and 145 ppm) twice for 4 h within seven days. Unsere Website wird von Internet Explorer 7 (und älteren Versionen) nicht uneingeschränkt unterstützt. The capacity of dissolving isobutyl acetate is very good with diluents such as aliphatic hydrocarbon, ethanol, toluene. Product Formulation Data for Ethyl Acetateno) Total no, of Total no, No. Based on results from the supporting substance n-butyl acetate, isobutyl acetate can be assessed to be not irritating to the eye. Its properties are similar to normal butyl acetate and are close to the properties of amyl acetate. The study is reliable with restrictions (RL2). The evaporation rate of 9 isobutyl acetate is slightly lower than the butylated acetate evaporation rate since the isobutyl acetate varnish is dried slightly faster than the butyl acetate-containing varnish. It is a colorless liquid that is only slightly soluble in water, but very soluble in most organic solvents. Rubus Rubus idaeus Rubus crataegifolius Rosaceae Rubus phoenicolasius. Thus, it is justified to use n-butyl acetate as supporting substance in the evaluation of irritation / corrosion effects of isobutyl acetate. This study was judged to be reliable with restrictions (RL2) and therefore selected as key study (read-across from supporting substance). Butyl acetate is one of the most important volatile solvents due to its high solvent power and high dilution capacity. Parameters were regressed for NRTL - HOC equations. In this GLP conform study according to OECD TG 405 New Zealandwhite rabbits were exposed to 0.1 mL of undiluted n-Butyl acetate (99% purity) and were observed for up to 14 days where necessary. Isobutyl acetate is desirable, neutral, colorless and with a fruity smell. A topological analysis for the quaternary system was performed. 1272/2008. Eye irritancy potential of n-butyl acetate was examined in a reliable study with rabbits (similar to OECD TG 405). Home Fragrance Like many esters it has a fruity or floral smell at low concentrations and occurs naturally in raspberries, pears and other plants. Afterwards, an experimental evaluation of the ternary LLE for the mixture isobutanol, acetic acid and water, was done at 283, 293 and 303 K. The complete set of experimental and reported data were used to correlate the corresponding binary parameters of the NRTL-HOC thermodynamic model. Isoamyl acetate has a strong odor which is described as similar to both banana and pear. Distinctly fresher and more diflusive (not really volatile) than the n-Butylester. study record in section 7.10.3). About Us Masculine Fragrance Overall no iritis occurred and only barely perceptible effects were seen on the cornea (score:1) as well as the conjunctivae (redness score:1, chemosis score: 1), which were all reversible within a maximum of 14 days (ECETOC, 1998). Iregren et al. Butyl acetate is commonly mixed with butanol. Diffusive, Main Synonyms:  2-methylpropyl 2-phenylacetate; Anther; Eglantine; Iso-butyl alpha-toluate; Iso-butyl Phenyl Acetate; Isobutyl Phenylacetate, See below for more description and documentation. From the topological analysis of the map, it is concluded that pure Isobutyl acetate cannot be obtained as pure product from a reactive distillation column as it is saddle node. Physical and chemical properties are only slightly influenced by this difference. Altogether, the authors of the study concluded a rather low irritating potential of n-butyl acetate. It is produced from the esterification of isobutanol with acetic acid. Isoamyl acetate is prepared by the acid catalyzed reaction (Fischer esterification) between isoamyl alcohol and glacial acetic acid as shown in the reaction equation below. Butylated acetate is neutral, colorless and has a specific odor. Butyl acetate can be used to produce essential oils, perfumes, spots and colored paper because it has a pleasant smell, good volatility, and good solubility. Both compounds are only different in the terminal methyl group position of the butyl alcohol part of the molecule. Isobutyl acetate has three isomers: n-butyl acetate, tert-butyl acetate, and sec-butyl acetate, which are also common solvents. Butyl acetate can be used to produce essential oils, perfumes, spots and colored paper because it has a pleasant smell, good volatility, and good solubility. Ingredients for Perfumery It is soluble in water. It has recently gained EPA volatile organic compound (VOC) exempt status. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). Diffusive. ... -Butyl Acetate. In one study throat irritation was already reported after 4 h exposure to 145 ppm. This is an extremely versatile ingredient, commonly used in floral accords but also essential in chocolate accords and useful in fruity complexes as well. To assess the skin, eye irritation / corrosion and respitatory irritation potential of isobutyl acetate, data for n-butyl acetate as supporting substance (structural analogue) will be used based on following reasons. Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice. N-Butyl Acetate was evaluated for dermal irritation in rabbits in a reliable study (RL2) which was selected as key study. By continuing you agree to the use of cookies. - 1910.134 App A | Occupational Safety and Health Administration", Occupational Safety and Health Administration,, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, This page was last edited on 9 November 2020, at 21:43.

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